US Patent Expiry Analysis - Q4 2024-25

Patent Expiry Analysis Q4 (2024–2025)



This dashboard presents an overview of upcoming patent expirations across key pharmaceutical products, highlighting the timeline, therapeutic diversity, and company-wise concentration. The analysis reflects potential areas for generic entry, market competition, and innovation turnover in the coming years.

Overall Snapshot

  • Total patents expiring: 64
  • Companies involved: 16
  • Brands affected: 16
  • Active ingredients covered: 16

The data indicates moderate concentration, with several companies holding multiple patents set to expire across diverse dosage forms and administration routes.

Company Insights

  • Karyopharm Therapeutics – 15 patents
  • SpringWorks Therapeutics – 10 patents
  • Sebela Pharmaceuticals – 9 patents
  • AbbVie Inc. – 5 patents
  • Genentech Inc. – 5 patents

These top five companies together account for nearly 70% of all expirations, suggesting that a handful of mid- to large-scale innovators dominate this patent cycle.

Patent Expiry Timeline

  • Near-term expirations (2025–2027): Limited activity, only 5 patents due.
  • Mid-term window (2032–2035): Peak period with 29 expirations, indicating a strong wave of opportunities for generics in this timeframe.
  • Long-term horizon (2037–2044): Gradual decline in expirations, showing extended protection for select products.

The 2032–2035 cluster marks a major phase for market shifts and competitive openings.

Route of Administration

  • Oral: 42 patents (65.63%) — primary dosage route, emphasizing solid oral formulations.
  • Intrauterine: 9 patents (14.06%)
  • Intravenous: 9 patents (14.06%)
  • Nasal: 4 patents (6.25%)

The dominance of oral formulations signals a continued focus on patient convenience and large-market drug formats.

Top Brands by Patent Count

  • Xpovio – 15 patents
  • Gomekli – 10 patents
  • Miudella – 9 patents
  • Emblaveo – 5 patents
  • Everysdi – 5 patents
  • Prezcobix – 4 patents
  • Neffy – 4 patents

Several brands exhibit multiple patent protections, indicating layered IP strategies for formulation, process, and delivery innovations.

Strategic Observations

The analysis highlights a maturing patent landscape with a clear mid-decade expiry concentration. Companies like Karyopharm and SpringWorks lead the list, positioning 2025–2035 as a key transition window for potential generic entry and portfolio diversification. The high share of oral dosage patents suggests that post-expiry competition may intensify in widely prescribed therapeutic areas.

Overall, Q4 data reflects a balanced mix of near-term and long-term expirations, offering both immediate and strategic opportunities for manufacturers, formulators, and licensing partners.