Ibuprofen is one of the most commonly used pain-relief drugs in the world. It’s taken for everyday problems like pain, swelling, and fever, and it is found in many generic and branded OTC medicines. What most people don’t see is the API (Active Pharmaceutical Ingredient) behind it, the core chemical that actually makes the drug work. Only a limited number of companies can manufacture ibuprofen API at a large, commercial scale.
In this blog, we break down the top 10 ibuprofen API manufacturers worldwide. You’ll see who these companies are, where they are located, and how they fit into the global ibuprofen supply chain.
Country: India
IOL Chemicals & Pharmaceuticals is widely recognized as one of the largest producers of ibuprofen API globally. It runs vertically integrated facilities that handle everything from raw materials to finished API, supplying major generic drugmakers worldwide.
The company emphasizes regulatory compliance and high-purity products that meet international pharmacopeial standards. IOL’s leadership in global API capacity helps stabilize ibuprofen supply chains.
Country: United States
Transo-Pharm USA focuses on sourcing and managing active pharmaceutical ingredients, including ibuprofen. While not always a direct manufacturer in the classic sense, its role as a supplier and API manager makes it key in distributing ibuprofen APIs to formulators, contract manufacturers, and finished dosage producers in regulated markets. This positioning gives it strength in North American supply networks.
Country: United States / China (origins)
Rochem International works on developing, sourcing, and supplying pharmaceutical ingredients of Chinese origin. It partners with manufacturing sites in China to provide APIs such as ibuprofen to global pharmaceutical companies. Rochem’s FDA-compliant supply channels help bridge the gap between Chinese manufacturing capacity and U.S./Western markets.
Country: India
Jai Radhe Sales acts primarily as a sourcing partner for pharmaceutical APIs, including ibuprofen. Although it does not disclose large-scale manufacturing, it serves as a key intermediary for global buyers looking to procure quality API from India’s broad supplier base.
Its role is crucial for smaller formulators or contract manufacturers needing reliable access to ibuprofen API stocks.
Country: India (global importer/distributor)
Pharm-RX Chemicals is known as a global importer and distributor of pharmaceutical active ingredients. While not a big manufacturer itself, its distribution network ensures that ibuprofen APIs manufactured in India and elsewhere are accessible to customers around the world, helping smooth over regional supply gaps.
Country: United States (CDMO partner)
ASolution Pharmaceuticals operates as a CDMO partner that supports APIs and specialty molecules through development and manufacturing services. Its involvement in ibuprofen API supply may be in custom manufacturing or contract development, making it an important partner for pharmaceutical firms that want both production and development expertise under one roof.
Country: India
HRV Pharma is a market expansion leader in the pharmaceutical space. Though information on its exact custom API capacity is limited publicly, it plays a role in expanding ibuprofen API distribution networks and helping smaller API manufacturers reach overseas markets. Its presence reflects the vibrant Indian sourcing ecosystem.
Country: India
Tenatra Exports connects Indian API manufacturers with global buyers, particularly in Europe and the Middle East. Its network helps move Indian-made ibuprofen API into regulated markets such as Germany, Switzerland, and Spain, making it an indirect but valuable piece of the API supply puzzle.
Country: India
Zeon Pharma Industries manufactures and supplies APIs and intermediates, including non-steroidal anti-inflammatory APIs like ibuprofen. With manufacturing capabilities focused on compliance and quality, Zeon Pharma serves both domestic Indian markets and international customers requiring GMP-certified APIs.
Country: India
Anlon Healthcare produces high-quality pharmaceutical bulk drugs and intermediates, including ibuprofen API. Its products are compliant with major international standards such as FDA, PMDA, KFDA, cGMP, and WHO-GMP, making it a trusted source for global pharmaceutical manufacturers.
The global ibuprofen API market is supported by a mix of large integrated producers, CDMO partners, and sourcing/distribution specialists. India and China dominate in terms of raw production capacity and export volumes, while companies based in the U.S. and Europe often play distribution or regulatory compliance roles.
Together, these players ensure that ibuprofen APIs are consistently available to formulators worldwide—whether for widely sold OTC pain relievers or niche formulations. If insight into supply networks, certifications, and regional manufacturing footprints is critical for your sourcing decisions, tracking global API manufacturers helps you avoid surprises and secure stable supply lines.
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