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  3. Biogen Teams Up With Dayra Therapeutics To Build The Next Wave Of Oral Immunology Drugs
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  • 27 Nov 2025
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  • News Article

Biogen Teams Up With Dayra Therapeutics to Build the Next Wave of Oral Immunology Drugs

When two innovation-heavy players join forces, the stakes rise fast. Biogen and Dayra Therapeutics have announced a new research collaboration that aims to do exactly that—push immunology treatment into a new era with oral macrocyclic peptides.

Why This Collaboration Matters?

Immunology drugs are powerful. But most come as injectables. Macrocyclic peptides may change that.

These compounds offer biologic-like efficacy but in an oral format. That means potentially easier dosing, more patient comfort, and fewer barriers to long-term treatment.

What Makes Oral Macrocyclic Peptides Unique?

  • They can act like biologics but still be taken orally.
  • They offer high specificity, which reduces off-target effects.
  • They can hit protein sites that traditional small molecules cannot reach.
  • They could challenge or even replace some antibody-based therapies.

What Biogen and Dayra Will Do?

Both companies will work together to:

  • Identify and validate macrocyclic peptide candidates.
  • Optimize those molecules for high-priority immunology targets.
  • Move the best candidates into development.
  • Scale manufacturing and commercialization through Biogen.

Dayra brings its cutting-edge discovery platform. Biogen brings deep immunology expertise and a global development engine.

Strategic Value for Biogen

For Biogen, this partnership strengthens its early-stage immunology pipeline. It also adds a clinically validated modality to its growing toolkit.

Biogen’s head of research, Jane Grogan, summed it up well:

“We are adding another potential best-in-class approach to target multiple high-value immunological conditions.”

Dayra’s Perspective

For Dayra, this collaboration is a validation moment. The company believes its macrocyclic peptide platform can unlock next-generation oral treatments.

Acting CEO Rami Hannoush highlighted the milestone:

“We look forward to working with Biogen to unlock the potential of this innovative class of medicines.”

The Financials

  • $50 million upfront payment to Dayra.
  • Additional development candidate acquisition payments.
  • Preclinical and clinical milestone payments for each program.
  • Biogen will record the upfront amount as R&D expense in Q4 2025.

The Bottom Line

This collaboration won’t reshape immunology overnight. But it signals something important: A move toward oral, highly targeted treatments that could give biologics a real challenge.

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