Angelini Pharma Partners with Quiver Bioscience to Advance Therapies for Genetic Epilepsies
Angelini Pharma, part of Angelini Industries, has entered a collaboration and licensing agreement with Quiver Bioscience.
The partnership aims to advance novel therapeutics for genetic epilepsies, including severe childhood-onset conditions.
Why This Collaboration Matters?
Genetic epilepsies remain among the most challenging CNS disorders to treat. Despite recent advances:
Many patients experience treatment-resistant seizures
Disease biology is often poorly understood
Available therapies address only a subset of conditions
This collaboration targets those gaps at their biological roots.
Combining AI-Driven Discovery with Epilepsy Expertise
The partnership brings together complementary strengths. Quiver Bioscience contributes:
Human neuronal disease models
Single-cell transcriptomics
Optical electrophysiology
AI-driven data integration and analytics
Angelini Pharma contributes:
Deep expertise in brain health
Proven epilepsy drug development capabilities
Global clinical and development infrastructure
The goal is to generate data sets of unprecedented depth and scale in epilepsy research.
Focus on Developmental and Epileptic Encephalopathies (DEEs)
A key focus area is Developmental and Epileptic Encephalopathies (DEEs).
DEEs are:
Rare genetic disorders affecting children
Characterized by severe, early-onset seizures
Associated with profound neurodevelopmental impairment
Although often caused by gene mutations, their functional and molecular consequences remain unclear in most cases. This limits effective drug development.
How Quiver’s Platform Changes the Equation?
Quiver’s technology links neuronal function to molecular drivers.
Its platform:
Uses altered neuronal electrophysiology as a disease classifier
Integrates multi-modal functional and molecular data
Applies AI to identify precision drug targets
The ultimate aim is to develop differentiated therapies capable of addressing multiple DEEs.
Deal Structure at a Glance
Under the multi-year agreement:
Quiver receives an undisclosed upfront payment
Angelini funds defined research activities
Angelini gains exclusive access to collaboration-generated data during the research term
Quiver is eligible for up to $120 million in milestone payments, plus royalties
Payments are triggered upon Angelini’s selection of drug targets from the collaboration.
Strategic Fit for Angelini Pharma
According to Angelini leadership, the deal supports long-term priorities.
It helps to:
Strengthen global presence in brain health
Expand the innovative CNS pipeline
Build leadership in epilepsy and rare neurological diseases
The partnership follows several strategic acquisitions and collaborations over the past two years.
About the Companies
Quiver Bioscience is a technology-driven biotech focused on AI-enabled discovery for neurological diseases, translating functional neuronal data into precision medicines.
Angelini Pharma is an international pharmaceutical company focused on brain health, including mental health and epilepsy, as well as consumer health.
Angelini Industries, founded in 1919 in Ancona, operates across health, industrial technology, and consumer goods, with over 5,800 employees in 21 countries.
Bottom line: This collaboration pairs deep epilepsy expertise with next-generation AI discovery. If successful, it could unlock new treatment options for some of the most underserved genetic epilepsy patients.